On-line monitoring of granule growth in high shear granulation by an image processing system.

@article{Watano2000OnlineMO,
  title={On-line monitoring of granule growth in high shear granulation by an image processing system.},
  author={Satoru Watano and E Numa and Kei Miyanami and Yoshifumi Osako},
  journal={Chemical \& pharmaceutical bulletin},
  year={2000},
  volume={48 8},
  pages={
          1154-9
        }
}
A novel system has been developed to continuously monitor granule growth in a high shear granulation. The system consists of an image processing system and a particle image probe comprising a CCD camera, lighting unit and air purge system. Segregation during powder mixing was investigated experimentally and the optimal positioning of the probe was determined. High shear granulation was conducted using pharmaceutical powders, and granule size and product's yield of various size ranges were… 
Feedback control in high shear granulation of pharmaceutical powders.
  • S. Watano, T. Numa, I. Koizumi, Y. Osako
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2001
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Chapter 10 Online monitoring
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