On-line monitoring of cell growth and cytotoxicity using electric cell-substrate impedance sensing (ECIS).

  title={On-line monitoring of cell growth and cytotoxicity using electric cell-substrate impedance sensing (ECIS).},
  author={Caide Xiao and John H. T. Luong},
  journal={Biotechnology progress},
  volume={19 3},
An on-line and continuous technique based on electric cell-substrate impedance sensing (ECIS) was developed for measuring the concentration and time response function of fibroblastic V79 cells exposed to mercury chloride and 1,3,5-trinitrobenzene (TNB). Attachment, spreading and proliferation of V79 fibroblastic cells cultured on a microarray of small gold electrodes precoated with fibronectin were detected as resistance changes. The response function was derived to reflect the resistance… CONTINUE READING


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