On-line monitoring of Phaffia rhodozyma fed-batch process with in situ dispersive Raman spectroscopy.

@article{Cannizzaro2003OnlineMO,
  title={On-line monitoring of Phaffia rhodozyma fed-batch process with in situ dispersive Raman spectroscopy.},
  author={Christopher Cannizzaro and Martin H Rhiel and Ian William Marison and Urs von Stockar},
  journal={Biotechnology and bioengineering},
  year={2003},
  volume={83 6},
  pages={
          668-80
        }
}
Since the yeast Phaffia rhodozyma was first described some 35 years ago, there has been significant interest in the development of commercial processes to exploit its ability to produce carotenoids (approximately 80% astaxanthin). However, the optimal conditions for carotenoid production are not well understood. A key limitation has been the lack of an appropriate sensor for on-line carotenoid quantification. In this study, an in situ Raman spectroscopy probe was used to monitor intracellular… CONTINUE READING

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