On-line microdialysis coupled solid-phase extraction to decrease matrix interference in the HPLC analysis of urinary ketamine and its metabolites.

@article{Chen2010OnlineMC,
  title={On-line microdialysis coupled solid-phase extraction to decrease matrix interference in the HPLC analysis of urinary ketamine and its metabolites.},
  author={Shing-Jung Chen and Fu-chou Cheng and J J Jen},
  journal={Journal of separation science},
  year={2010},
  volume={33 13},
  pages={2010-6}
}
A microdialysis sampling (MDS) on-line SPE (MDS/SPE) has been applied to redeem the detection after dilution to decrease matrix interference in the analysis of ketamine (K) and its two main metabolites, norketamine (NK) and dehydronorketamine (DHNK) in urine by HPLC. After being filtrated, diluted and adjusting the pH, K and its metabolites in the diluted… CONTINUE READING