On-line heat flux measurements improve the culture medium for the growth and productivity of genetically engineered CHO cells

@article{Guan1999OnlineHF,
  title={On-line heat flux measurements improve the culture medium for the growth and productivity of genetically engineered CHO cells},
  author={Yue Guan and Richard B. Kemp},
  journal={Cytotechnology},
  year={1999},
  volume={30},
  pages={107-120}
}
With the increasingly competitive commercial production of target proteins by hybridoma and genetically engineered cells, there is an urgent requirement for biosensors to monitor and control on-line and in real time the growth of cultured cells. Since growth is accompanied by an enthalpy change, heat dissipation measured by calorimetry could act as an index… CONTINUE READING