On-line detection of sleep-wake states and application to produce intermittent hypoxia only in sleep in rats.

@article{Hamrahi2001OnlineDO,
  title={On-line detection of sleep-wake states and application to produce intermittent hypoxia only in sleep in rats.},
  author={H Hamrahi and Becky Chan and Richard L Horner},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 6},
  pages={2130-40}
}
Sleep-disordered breathing is associated with adverse clinical consequences such as daytime sleepiness and hypertension. The mechanisms behind these associations have been studied in animal models, especially rats, but intermittent stimuli such as hypoxia have been applied without reference to sleep-wake states. To determine mechanisms underlying the adverse physiological consequences of stimuli associated with sleep-disordered breathing requires criteria for detection of sleep-wake states on… CONTINUE READING
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