On-line Solid Phase Extraction Coupled with Liquid Chromatography Tandem Mass Spectrometry for the Determination of Codeine in Human Plasma

  • Alessandro de C. Cruza, Eunice M. Suenagab, José Pedrazzolia
  • Published 2017


A specific LC-MS/MS method was developed and validated for automated determination of codeine in human plasma, using online solid phase extraction (SPE) system coupled with positive ion electrospray ionization tandem mass spectrometry. The method allowed plasma direct injection onto cartridge without sample pre-treatment. Total analysis time per run was 3… (More)


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