On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure

@inproceedings{Pennell2011OnII,
  title={On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure},
  author={Dudley J. Pennell and John Paul Carpenter and Michael Roughton and Z. Ioav Cabantchik},
  booktitle={Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance},
  year={2011}
}
BACKGROUND Trials of iron chelator regimens have increased the treatment options for cardiac siderosis in beta-thalassemia major (TM) patients. Treatment effects with improved left ventricular (LV) ejection fraction (EF) have been observed in patients without overt heart failure, but it is unclear whether these changes are clinically meaningful. METHODS This retrospective study of a UK database of TM patients modelled the change in EF between serial scans measured by cardiovascular magnetic… CONTINUE READING
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