On how insulin may influence ageing and become atherogenic throughout the insulin-like growth factor-1 receptor pathway: in vitro studies with human vascular smooth muscle cells.

@article{Ruiztorres2005OnHI,
  title={On how insulin may influence ageing and become atherogenic throughout the insulin-like growth factor-1 receptor pathway: in vitro studies with human vascular smooth muscle cells.},
  author={A. Ruiz-torres and Rosario Morales Lozano and Jos{\'e} Manuel Valle Mel{\'o}n and Raffaele Carraro},
  journal={Gerontology},
  year={2005},
  volume={51 4},
  pages={
          225-30
        }
}
BACKGROUND It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. OBJECTIVES This study focuses on the pathway by which insulin induces proliferation and mobility in vascular smooth muscle cells (SMCs) compared with that of insulin-like growth factor-1 (IGF-1), because they are two basic phenomena for atherogenesis that could also help to understand the role of insulin in the ageing process. METHODS Bromodeoxyuridine DNA… CONTINUE READING

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