On fluctuation analysis: a new, simple and efficient method for computing the expected number of mutants

@article{Sarkar1992OnFA,
  title={On fluctuation analysis: a new, simple and efficient method for computing the expected number of mutants},
  author={Sourav Sarkar and W. T. Ma and G. V. H. Sandri},
  journal={Genetica},
  year={1992},
  volume={85},
  pages={173-179}
}
Fluctuation analysis, which is often used to demonstrate random mutagenesis in cell lines (and to estimate mutation rates), is based on the properties of a probability distribution known as the Luria-Delbrück distribution (and its generalizations). The two main new results reported in this paper are (i) a simple, completely general, and computationally efficient procedure for calculating probability distributions arising from fluctuation analysis and (ii) the formula for this procedure when… CONTINUE READING