On estimation of the variance in Cochran-Armitage trend tests for genetic association using case-control studies.

Abstract

The Cochran-Armitage trend test has been used in case-control studies for testing genetic association. As the variance of the test statistic is a function of unknown parameters, e.g. disease prevalence and allele frequency, it must be estimated. The usual estimator combining data for cases and controls assumes they follow the same distribution under the… (More)

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Cite this paper

@article{Zheng2006OnEO, title={On estimation of the variance in Cochran-Armitage trend tests for genetic association using case-control studies.}, author={Gang Zheng and Joseph L. Gastwirth}, journal={Statistics in medicine}, year={2006}, volume={25 18}, pages={3150-9} }