On estimating the linkage of marker genes to viability genes controlling inbreeding depression

@article{Fu1994OnET,
  title={On estimating the linkage of marker genes to viability genes controlling inbreeding depression},
  author={Yong Bi Fu and Kermit Ritland},
  journal={Theoretical and Applied Genetics},
  year={1994},
  volume={88},
  pages={925-932}
}
Statistical properties and extensions of Hedrick and Muona's method for mapping viability alleles causing inbreeding depression are discussed in this paper. Their method uses the segregation ratios among selfed progeny of a marker-locus heterozygote to estimate the viability reduction, “s”, of an allele and its recombination fraction, “c”, with the marker. Explicit estimators are derived for c and s, including expressions for their variances. The degree of estimation bias is examined for cases… CONTINUE READING
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