On epistasis: why it is unimportant in polygenic directional selection.

@article{Crow2010OnEW,
  title={On epistasis: why it is unimportant in polygenic directional selection.},
  author={James F. Crow},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2010},
  volume={365 1544},
  pages={
          1241-4
        }
}
There is a difference in viewpoint of developmental and evo-devo geneticists versus breeders and students of quantitative evolution. The former are interested in understanding the developmental process; the emphasis is on identifying genes and studying their action and interaction. Typically, the genes have individually large effects and usually show substantial dominance and epistasis. The latter group are interested in quantitative phenotypes rather than individual genes. Quantitative traits… CONTINUE READING
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