On deriving the dose-effect relation of an unknown second component: an example using buprenorphine preclinical data.

Abstract

Buprenorphine, like many other drugs, displays a biphasic dose-response relation ('hormesis'), viz., its antinociceptive effect in some preclinical models increases up to some dose level (often achieving 100% effect) and decreases at high-doses. A decreasing component was evident in the tail-flick tests described here, occurring in both the mouse and the… (More)
DOI: 10.1016/j.drugalcdep.2009.12.014

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@article{Tallarida2010OnDT, title={On deriving the dose-effect relation of an unknown second component: an example using buprenorphine preclinical data.}, author={Ronald J. Tallarida and Alan Cowan and R B Raffa}, journal={Drug and alcohol dependence}, year={2010}, volume={109 1-3}, pages={126-9} }