On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.

@article{Pedersen2011OnDE,
  title={On depolarization-evoked exocytosis as a function of calcium entry: possibilities and pitfalls.},
  author={Morten Gram Pedersen},
  journal={Biophysical journal},
  year={2011},
  volume={101 4},
  pages={793-802}
}
Secretion from many endocrine cells is a result of calcium-regulated exocytosis due to Ca²⁺ influx. Using the patch-clamp technique, voltage pulses can be applied to the cells to open Ca²⁺ channels, resulting in a measurable Ca²⁺ current, and evoke exocytosis, which can be seen as an increase in membrane capacitance. A common tool for evaluating the relation between Ca²⁺ influx and exocytosis is to plot the increase in capacitance (ΔC(m)) as a function of the integral of the measured Ca… CONTINUE READING