On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy

  title={On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy},
  author={Esther Krook-Magnuson and Caren Armstrong and Mikko Oijala and Ivan Soltesz},
  booktitle={Nature communications},
Temporal lobe epilepsy is the most common type of epilepsy in adults, is often medically refractory, and due to broad actions and long-time scales, current systemic treatments have major negative side-effects. However, temporal lobe seizures tend to arise from discrete regions before overt clinical behaviour, making temporally and spatially specific treatment theoretically possible. Here we report the arrest of spontaneous seizures using a real-time, closed-loop, response system and in vivo… CONTINUE READING
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