On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver

@inproceedings{Theurl2016OndemandED,
  title={On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver},
  author={Igor M Theurl and Ingo Hilgendorf and Manfred Nairz and Piotr Z. Tymoszuk and David Haschka and Malte Asshoff and Shun He and Louisa M. S. Gerhardt and Tobias A. W. Holderried and Markus Seifert and Sieghart Sopper and Ashley M. Fenn and Atsushi Anzai and Sara Rattik and Cameron S McAlpine and Milan Theurl and Peter Wieghofer and Yoshiko Iwamoto and Georg F Weber and Nina K Harder and Benjamin G. Chousterman and Tara Arvedson and Mary Mckee and Fudi Wang and Oliver Lutz and Emanuele Rezoagli and Jodie L Babitt and Lorenzo Berra and Marco Prinz and Matthias Nahrendorf and Guenter Weiss and Ralph Weissleder and Herbert Y. Lin and Filip K Swirski},
  booktitle={Nature Medicine},
  year={2016}
}
Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal. In various pathophysiological conditions, however, erythrocyte life span is compromised severely, which threatens the organism with anemia and iron toxicity. Here we identify an on-demand mechanism that clears erythrocytes and recycles iron. We show that monocytes that express high levels… CONTINUE READING