On-demand cleavable linkers for radioimmunotherapy.

Abstract

Radioimmunotherapy (RIT) using radiolabeled antibodies or its fragments holds great promise for cancer therapy. However, its clinical potential is often limited by the undesirable radiation exposure to normal organs such as liver, kidney, and bone marrow. It is important to develop new strategies in RIT that enable protection of vital organs from radiation… (More)
DOI: 10.1007/978-1-60327-003-8_11

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