On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.

  title={On commonness and rarity of thyroid hormone resistance: a discussion based on mechanisms of reduced sensitivity in peripheral tissues.},
  author={E. Tj{\o}rve and K. M. C. Tj{\o}rve and J. O. Olsen and R. Senum and H. Oftebro},
  journal={Medical hypotheses},
  volume={69 4},
  • E. Tjørve, K. M. C. Tjørve, +2 authors H. Oftebro
  • Published 2007
  • Biology, Medicine
  • Medical hypotheses
  • Reduced sensitivity to thyroid hormone (TH) in peripheral tissues can occur as defects in TH transport into the cell, intracellular TH metabolism, cytosolic mechanisms, TH entry into the nucleus, thyroxin receptors (TRs) and receptor binding, transcription and post-transcriptional mechanisms. Current literature reveals an extensive list of mutations, drugs, toxins, metabolites and autoimmune antibodies that may impair TH action in the cell, but such impairment may not be picked up by assays of… CONTINUE READING
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