On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis.

@article{Taller2015OnchipSA,
  title={On-chip surface acoustic wave lysis and ion-exchange nanomembrane detection of exosomal RNA for pancreatic cancer study and diagnosis.},
  author={Daniel Taller and Katherine M. Richards and Zdenek Slouka and Satyajyoti Senapati and Reginald Hill and David B. Go and Hsueh-Chia Chang},
  journal={Lab on a chip},
  year={2015},
  volume={15 7},
  pages={
          1656-66
        }
}
There has been increasing evidence that micro and messenger RNA derived from exosomes play important roles in pancreatic and other cancers. In this work, a microfluidics-based approach to the analysis of exosomal RNA is presented based on surface acoustic wave (SAW) exosome lysis and ion-exchange nanomembrane RNA sensing performed in conjunction on two separate chips. Using microRNA hsa-miR-550 as a model target and raw cell media from pancreatic cancer cell lines as a biological sample, SAW… CONTINUE READING

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Exosomes in Pancreatic Cancer: from Early Detection to Treatment

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