On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging.

@article{Peyman2016OnchipPO,
  title={On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging.},
  author={Sally A. Peyman and James R. Mclaughlan and Radwa H Abou-Saleh and Gemma Marston and Benjamin R G Johnson and Steven Freear and Patricia Louise Coletta and Alexander F. Markham and Stephen D. Evans},
  journal={Lab on a chip},
  year={2016},
  volume={16 4},
  pages={679-87}
}
Micron-sized lipid-stabilised bubbles of heavy gas have been utilised as contrast agents for diagnostic ultrasound (US) imaging for many years. Typically bubbles between 1 and 8 μm in diameter are produced to enhance imaging in US by scattering sound waves more efficiently than surrounding tissue. A potential area of interest for Contrast Enhanced Ultrasound (CEUS) are bubbles with diameters <1 μm or 'nanobubbles.' As bubble diameter decreases, ultrasonic resonant frequency increases, which… CONTINUE READING

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