On catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity

@article{Costall1974OnCA,
  title={On catalepsy and catatonia and the predictability of the catalepsy test for neuroleptic activity},
  author={Brenda Costall and Robert J. Naylor},
  journal={Psychopharmacologia},
  year={1974},
  volume={34},
  pages={233-241}
}
The neuroleptic agents peromide and spiroxatrine induced an immobility in the rat which, in appearance, more resembled morphine catatonia than haloperidol catalepsy. Therefore, in a attempt to differentiate the behavioural states termed catalepsy and catatonia, haloperidol and morphine were closely compared using drug interaction and brain lesion studies. Atropine abolished or reduced the effects of haloperidol, peromide and spiroxatrine but not morphine, whilst morphine and spiroxatrine were… CONTINUE READING

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