On association between cortical 5-HT2A receptors and behavior in rats with experimental thyroid disturbances.

@article{Tikhonova2005OnAB,
  title={On association between cortical 5-HT2A receptors and behavior in rats with experimental thyroid disturbances.},
  author={Maria A. Tikhonova and Alexander Kulikov and Ekaterina I Lebedeva and Natalia N Barykina and Tamara G. Amstislavskaya and Nina K. Popova},
  journal={Pharmacology, biochemistry, and behavior},
  year={2005},
  volume={82 3},
  pages={506-14}
}
Thyroid hormones (TH) were hypothesized to affect behavior via neurotransmission alterations. The present study was aimed to reveal effects of chronic TH deficit and excess on some types of adaptive behavior (catalepsy, acoustic startle reflex, open-field performance), sexual arousal and cerebral 5-HT2A serotonin receptors of adult Wistar rats. Administration of thyroxine synthesis inhibitor, propylthiouracil (PTU, 50 mg/l, 28 days), in drinking water produced substantial decrease in plasma… CONTINUE READING