The paper deals with a pressing problem: activities of centers of sanitary and epidemiological survey under new economic conditions. The authors discuss problems of centralization and adaptation of sanitary epidemiological service under present-day economic conditions. They analyze the opinions of heads of sanitary epidemiological institutions from various regions of Russia on the present-day status of organization and management of the service. Assessment of the sources of additional financing of the institutions, of new forms of labor organization of departments and specialists, of distribution of additional allotments at sanitary epidemiological institutions is presented. Suggestions on improvement of the activities of institutions engaged in sanitary epidemiological survey under conditions of reformation of sanitary epidemiological service are offered.