On a possible epigenetic mechanism(s) of tumor cell heterogeneity

Abstract

It is a currently well-accepted view that both human and animal tumors consist of heterogeneous rather than homogeneous populations of tumor cells (reviewed in 1-3). This cellular diversity within individual tumors represents the most formidable obstacle to the development of any uniform approach to the therapy of neoplasia (2-5). It is therefore essential… (More)
DOI: 10.1007/BF00048568

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