On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes.

  title={On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes.},
  author={Ravikumar Rajamanonmani and C{\'e}line Nguefeu Nkenfou and Paula Clancy and Yin Hoe Yau and Susana Geifman Shochat and Soila Sukupolvi-Petty and Wouter Schul and Michael S Diamond and Subhash G. Vasudevan and Julien Lescar},
  journal={The Journal of general virology},
  volume={90 Pt 4},
The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain is the primary target of the humoral immune response. In particular, the C-terminal Ig-like domain III of E, which is exposed at the surface of the viral particle, forms an attractive antigen for raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against a dengue virus (DENV) serotype 2 recombinant domain III, cross-reacts with corresponding domains… CONTINUE READING
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