On a New Strategy of Preventive Oncology

  title={On a New Strategy of Preventive Oncology},
  author={Levon Mkrtchyan},
  journal={Neurochemical Research},
  • L. Mkrtchyan
  • Published 30 January 2010
  • Medicine, Biology
  • Neurochemical Research
The etiology of cancer is much wider than separately taken causal agent and rests against the most complicated interrelation and mutuality of many external and internal influences. Our researches with use of fluorescing antibodies to AFP, CEA and Ca-19-9 have shown that they are intensively besieged on a surface of cultivated malignant cells. It is the basic mechanism of tolerance and immunological escape, which is similar to pregnancy when «the maximal immunological most favored status” to… 

Antioxidative effects of proteglycans of embryonic genesis in streptozotocin-induced diabetic rats

The prophylactic injection of the PEG demonstrated overall antioxidative effect, with prevention of changes in prooxidative markers.

Antioxidative effects of proteoglycans of embryonic genesis in streptozotocin-induced diabetic rats

The prophylactic injection of the PEG demonstrated overall antioxidative effect, with prevention of changes in prooxidative markers.

Oxidative Processes and Histopathology of Madopar-Induced Neurodegeneration and its Experimental Therapy

Nurodegenerative diseases (NDD) such as Alzheimer's disease (AD), Parkinson's disease (PD) are the third most common cause of mortality after cardiovascular and oncological diseases. In PD, most of



Cancer precursors and their control by BCG.

  • S. Rosenthal
  • Medicine, Biology
    Developments in biological standardization
  • 1986
It is demonstrated that in some 85,353 BCG vaccinated newborns followed over a period of 20 years, there was an overall 74 percent reduction in the death rate from all forms of cancer when compared to a similar group not vaccinated.


It is considered that one of promising directions in struggle against cancer is vaccine prophylaxis for high oncological risk groups by the approbation of a wide pool of normal embryonic proteins, with which adults and aged persons do not come across for decades.

Cancer and Pregnancy Share Similar Mechanisms of Immunological Escape

The process of immunological escape in cancer and pregnancy is based on similar mechanisms, and loss or downregulation of classical HLA antigens as well as the presence of non-classical HLA-G molecules seem to be the most effective mechanisms.

Can fetal antigens be used for prophylactic immunization?

Even if the inoculation of fetal tissue cells were a dependable and uniformly successful method of protecting experimental animals against chemically or virally induced tumours, it would for obvious

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.

These studies provide clinical evidence for a subpopulation of chemotherapy-resistant breast cancer-initiating cells and, in combination with conventional therapy, specific pathway inhibitors may provide a therapeutic strategy for eliminating these cells to decrease recurrence and improve long-term survival.

Normal stem cells and cancer stem cells: the niche matters.

An examination of the interaction between stem cells and their niche will enhance understanding of the process of cancer development, invasiveness, and metastasis and reveal possible targets for cancer treatment.

Vaccines and vaccination.

  • G. Ada
  • Biology, Medicine
    The New England journal of medicine
  • 2001
Table 1 lists infections for which there are now licensed vaccines and those for which a candidate vaccine has undergone a phase 3 clinical trial, indicating that a vaccine will probably be licensed within 5 to 10 years.

Stem Cells,Cancer and Cancer Stem Cells

Research data show that more resistant stem cells than common cancer cells exist in cancer patients, and to identify unrecognized differences between cancer stem cells and cancer cells might be able to develop effective classification, diagnose and treat for cancer.

Editorial staff

[Vaccines and vaccination].

  • A. Capron
  • Medicine
    Revue d'epidemiologie et de sante publique
  • 1997