On Virulence

  title={On Virulence},
  author={Arturo Casadevall and Liise-Anne Pirofski},
  pages={2 - 2}
Journal names are important because they often define the scope of the publication. A journal’s name must be sufficiently specific to define the major interest of the publication but not too narrow to prevent its rapid obsolescence as fields evolve. In naming this journal ‘Virulence’ the creators of this scientific publishing venue have staked a remarkably broad scope and it is worthwhile to reflect on the choice of the word and what this could mean for the future of the journal. No other major… Expand
Insects emerge as valuable model hosts to explore virulence
Insects emerge as valuable model hosts to explore virulence, to show that Toll-deficient strains are both resistant to infection by human pathogenic fungi belonging to Pneumocystis spp, and promising as models for studying pathogenesis of insects. Expand
The adaptive evolution of virulence: a review of theoretical predictions and empirical tests
The results show that there have been some notable successes in integrating theory and data but also that theory and empiricism in this field do not ‘speak’ to each other very well. Expand
Virulence evolution and the trade‐off hypothesis: history, current state of affairs and the future
It is argued that the trade‐off hypothesis and its basic extensions are necessary to assess the qualitative impacts of virulence management strategies and many processes such as pathogen adaptation to within‐host competition, interactions with the immune system and shifting transmission routes, will all be interrelated making sweeping evolutionary predictions harder to obtain. Expand
The pathogenic Yersiniae—advances in the understanding of physiology and virulence
  • M. S. Francis
  • Biology, Medicine
  • Front. Cell. Infect. Microbiol.
  • 2013
This special research topic on the pathogenic Yersiniae is a compilation of reviews and research articles that highlight current knowledge and new developments in these areas of Yersinia pathophysiology. Expand
Beyond Mortality: Sterility As a Neglected Component of Parasite Virulence
The aim in this Opinion piece is to discuss what is understood about sterility virulence evolution, its adaptive potential, and the implications for parasites that utilize a combination of host survival and reproductive resources. Expand
Phytophthora ramorum is a generalist plant pathogen with differences in virulence between isolates from infectious and dead-end hosts
Isolates from non-transmissive oaks were significantly less pathogenic both on oaks and bays than isolates from infectious hosts, suggesting P. ramorum is a generalist pathogen that lacks host specificity. Expand
Invasive Mold Infections: Virulence and Pathogenesis of Mucorales
Mucorales have been increasingly reported as cause of invasive fungal infections in immunocompromised subjects, particularly in patients with haematological malignancies or uncontrolled diabetesExpand
Characterisation of novel bat influenza A virus NS1 proteins
The author’s dissertation aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about concrete mechanical properties such as E-modulus and compressive strength. Expand
When parasites are selected to kill the young
A stage-structured (juvenile-adult) epidemiological model is developed and the evolutionary outcomes of stage-specific virulence under the classic assumption of a transmission-virulence trade-off are examined, showing that selection on virulence against adults remains consistent with the classic theory. Expand
The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence
  • M. Boots
  • Biology, Medicine
  • PLoS biology
  • 2015
Empirically, vaccination against Marek’s disease has favored higher virulence; without intervention, the birds die too quickly for any transmission to occur, but vaccinated hosts can both stay alive longer and shed the virus. Expand