On T-cell dynamics and the hyperactivation theory of AIDS pathogenesis.

  title={On T-cell dynamics and the hyperactivation theory of AIDS pathogenesis.},
  author={David Wick},
  journal={Mathematical biosciences},
  volume={158 2},
  • David Wick
  • Published 1999 in Mathematical biosciences
In an earlier article the author proposed a model of T cell dynamics in which rising activation rates produced falling T-cell counts. Here I show that, in a model of this type, apoptosis and proliferation must nearly balance. Hence, small perturbations of these processes could have large consequences, a fact that may be relevant to AIDS pathogenesis. In addition, I show the model can reproduce all decay rates found by McLean and Michie for cells with radiation-induced chromosome damage… CONTINUE READING
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