On Serotonin and Migraine: A Clinical and Pharmacological Review

@article{Ferrari1993OnSA,
  title={On Serotonin and Migraine: A Clinical and Pharmacological Review},
  author={Michel Dominique Ferrari and Pramod R. Saxena},
  journal={Cephalalgia},
  year={1993},
  volume={13},
  pages={151 - 165}
}
Migraine patients have chronically low systemic 5-HT, predisposing them to develop migrainous headache once an attack has been initiated. Changes in platelet 5-HT content are not causally related, but reflect similar changes at a neuronal level. Stimulation of vascular 5-HT1 receptors, probably located in the vessel wall within the dural vascular bed, may alleviate the headache and associated symptoms, but does not interact with earlier mechanisms within the pathophysiological cascade. These… 

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