On Serotonin and Migraine: A Clinical and Pharmacological Review

  title={On Serotonin and Migraine: A Clinical and Pharmacological Review},
  author={M. Ferrari and P. Saxena},
  pages={151 - 165}
  • M. Ferrari, P. Saxena
  • Published 1993
  • Medicine
  • Cephalalgia
  • Migraine patients have chronically low systemic 5-HT, predisposing them to develop migrainous headache once an attack has been initiated. Changes in platelet 5-HT content are not causally related, but reflect similar changes at a neuronal level. Stimulation of vascular 5-HT1 receptors, probably located in the vessel wall within the dural vascular bed, may alleviate the headache and associated symptoms, but does not interact with earlier mechanisms within the pathophysiological cascade. These… CONTINUE READING
    205 Citations

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