On Serotonin and Migraine: A Clinical and Pharmacological Review

  title={On Serotonin and Migraine: A Clinical and Pharmacological Review},
  author={Michel Dominique Ferrari and Pramod R. Saxena},
  pages={151 - 165}
Migraine patients have chronically low systemic 5-HT, predisposing them to develop migrainous headache once an attack has been initiated. Changes in platelet 5-HT content are not causally related, but reflect similar changes at a neuronal level. Stimulation of vascular 5-HT1 receptors, probably located in the vessel wall within the dural vascular bed, may alleviate the headache and associated symptoms, but does not interact with earlier mechanisms within the pathophysiological cascade. These… 

Tables from this paper

Serotonin and migraine: a reconsideration of the central theory

The alteration of peripheral and central 5-HT parameters in migraine patients is discussed and the interpretation of the effects of some serotonergic drugs and recent neuroimaging studies give major evidence for this cascade of events.

Serotonin and Migraine: Biology and Clinical Implications

The original and most recent findings that support a role for altered serotonergic neurotransmission in the manifestation of migraine headache are presented and discussed.

Serotonin and Migraine: The Latest Developments

The majority of available evidence points towards a systemic disturbance of serotonin metabolism in patients with migraine, and many of the medications used for acute and prophylactic treatment have actions on the serotonergic system.

Dopamine and Migraine: A Review of Pharmacological, Biochemical, Neurophysiological, and Therapeutic Data

It is concluded that data suggesting a primary role for the dopaminergic system in migraine pathogenesis are unconvincing and a reduced release of serotonin between attacks could lower dopamine release which would lead to receptor hypersensitivity.

Plasticity of 5‐HT2A Serotonin Receptor in Patients With Analgesic‐Induced Transformed Migraine

Findings indicate that 5‐HT2A serotonin receptor system is altered in patients with transformed migraine with analgesic overuse, and receptor plasticity may be an important step in the pathogenic mechanism of transformed migraine.

Chapter 4 – Pharmacology

5‐HT1A Receptor hypersensitivity in migraine is suggested by the m‐chlorophenylpiperazine test

The prolactin (PRL) and cortisol responses to m-chlorophenylpiperazine (mCPP), a selective 5-HT1A,5-HT2A/C receptor agonist, were monitored to investigate the type of cerebral serotonin receptors that may be altered in migraine and suggest that 5- HT2C receptors are normal in migraine.

Pathophysiology, epidemiology, and impact of migraine.

  • N. Mathew
  • Medicine, Psychology
    Clinical cornerstone
  • 2001

Migraine and Cluster Headache-Their Management with Sumatriptan: A Critical Review of The Current Clinical Experience

Sumatriptan was equally effective regardless of migraine type or duration of migraine symptoms and was also effective in relieving associated migraine symptoms like nausea and vomiting.

The Role of 5-HT1B/1D Receptors in the Treatment of Migraine

This review focuses on the relationship between the efficacy of sumatriptan and other migraine agents and their effects on specific 5-HT receptors in rodent models.



5-HT(1)-like receptor agonists and the pathophysiology of migraine.

Migraine, Serum Serotonin and Platelet 5–HT2 Receptors

It is verified that migraine with aura differs biochemically from migraine without aura.

[Treatment of migraine attacks with sumatriptan].

The serotonin agonist, sumatriptan, is a new, highly promising alternative treatment for migraine that has a vasoconstricting effect on the blood vessels dilated during an attack. In addition,

Induction of migrainelike headaches by the serotonin agonist m‐chlorophenylpiperazine

In a study of serotonin (5‐HT) function in patients with eating disorders and healthy control subjects, severe headaches with features of common migraine occurred unexpectedly in 28 of 52 subjects

Serotonin metabolism in migraine

It is hypothesize that systemic 5-HT metabolism is enhanced in migraineurs during headache-free periods and transiently decreases during attacks, presumably due to a fall in enzymatic degradation.

Drug treatment of migraine.

Ergotamine tartrate is the most reliable agent for the relief of migraine, and the high frequency of selfmedication with other preparations requires examination, but adequately controlled trials showing the superiority of such combinations over ergotamine alone are lacking.

Effects on Migraine Headache of MDL 72,222, an Antagonist at Neuronal 5-HT Receptors. Double-Blind, Placebo-Controlled Study

The results are consistent with the hypothesis that the pain of migraine is related to activation of neuronal 5-HT receptors and suggest that compounds such as MDL 72,222, which block neuronal 5 -HT receptors, could be useful new therapeutic agents for the management of migraine.

5-HT receptors in human and animal cerebrovasculature.

  • A. A. Parsons
  • Medicine, Biology
    Trends in pharmacological sciences
  • 1991

The Platelet and The Neuron: Two Cells in Focus in Migraine

It is proposed that migraine is associated with a lowered threshold for stimulus response in both platelets andserotonergic neurons and that the alterations in platelet function reflect central serotonergic disturbances.