On Phylogenetic Tests of Irreversible Evolution

@inproceedings{Goldberg2008OnPT,
  title={On Phylogenetic Tests of Irreversible Evolution},
  author={Emma Goldberg and Boris Igi{\'c}},
  booktitle={Evolution; international journal of organic evolution},
  year={2008}
}
Abstract “Dollo's law” states that, following loss, a complex trait cannot reevolve in an identical manner. Although the law has previously fallen into disrepute, it has only recently been challenged with statistical phylogenetic methods. We employ simulation studies of an irreversible binary character to show that rejections of Dollo's law based on likelihood-ratio tests of transition rate constraints or on reconstructions of ancestral states are frequently incorrect. We identify two major… 

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