On Inhibition of Vit. K Activity by Sulfaquinoxaline in Chicks∗ †

@article{Griminger1957OnIO,
  title={On Inhibition of Vit. K Activity by Sulfaquinoxaline in Chicks∗ †},
  author={Paul Griminger},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1957},
  volume={96},
  pages={757 - 760}
}
  • P. Griminger
  • Published 1 December 1957
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine
Conclusion Increasing doses of vit. K-active compounds are necessary to overcome the inhibition of prothrombin formation in chicks fed increasing levels of sulfaquinoxaline. The drug will hasten depletion of prothrombin in chicks kept on a K-deficient ration. When a single dose of about 50 mg of sulfaquinoxaline was administered orally with varying levels of menadione, one mole of menadione appeared to overcome the inhibitory effect of more than 800 moles of sulfaquinoxaline. 
12 Citations
Vitamin K Induced Prothrombin Formation: Antagonism by Actinomycin D
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