OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis.

@article{Sansonetti1991OmpBA,
  title={OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis.},
  author={Philippe J Sansonetti and J Arondel and Arnaud Fontaine and H{\'e}l{\`e}ne d'Hauteville and Maria Lina Bernardini},
  journal={Vaccine},
  year={1991},
  volume={9 6},
  pages={
          416-22
        }
}
Genetic and molecular data now available on the pathogenic properties of Shigella flexneri allow rational design of live attenuated vaccine strains. The genes required at given steps of the infection process can be selectively mutated to impair the bacterium's capacity to interact with intestinal epithelial cells and/or survive within intestinal tissues in general. We have tested two mutations in S. flexneri serotype 5a (M90T) which, alone or in combination, have yielded promising results when… CONTINUE READING

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