OmpA is the critical component for Escherichia coli invasion-induced astrocyte activation.

@article{Wu2009OmpAIT,
  title={OmpA is the critical component for Escherichia coli invasion-induced astrocyte activation.},
  author={Hsueh-Hsia Wu and Yi-yuan Yang and Wen-Shyang Hsieh and Chi-Hsin Lee and Sy-Jye Leu and Mei-Ru Chen},
  journal={Journal of neuropathology and experimental neurology},
  year={2009},
  volume={68 6},
  pages={677-90}
}
Escherichia coli is the major Gram-negative bacterial pathogen in neonatal meningitis. Outer membrane protein A (OmpA) is a conserved major protein in the E. coli outer membrane and is involved in several host-cell interactions. To characterize the role of OmpA in the invasion of astrocytes by E. coli, we investigated OmpA-positive and OmpA-negative E. coli strains. Outer membrane protein A E44, E105, and E109 strains adhered to and invaded C6 glioma cells 10- to 15-fold more efficiently than… CONTINUE READING

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