Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis.

@article{Saito2010OmnipotentRO,
  title={Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis.},
  author={Kazuki Saito and Kan Kobayashi and Miki Wada and Izumi Kikuno and Akira Takusagawa and Masahiro Mochizuki and Toshio Uchiumi and Ryuichiro Ishitani and Osamu Nureki and Koichi Ito},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 45},
  pages={19242-7}
}
The molecular mechanisms of translation termination and mRNA surveillance in archaea remain unclear. In eukaryotes, eRF3 and HBS1, which are homologous to the tRNA carrier GTPase EF1α, respectively bind eRF1 and Pelota to decipher stop codons or to facilitate mRNA surveillance. However, genome-wide searches of archaea have failed to detect any orthologs to both GTPases. Here, we report the crystal structure of aRF1 from an archaeon, Aeropyrum pernix, and present strong evidence that the… CONTINUE READING

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