Omission of Nitrous Oxide during Anesthesia Reduces the Incidence of Postoperative Nausea and Vomiting: A Meta-Analysis

@article{Divatia1996OmissionON,
  title={Omission of Nitrous Oxide during Anesthesia Reduces the Incidence of Postoperative Nausea and Vomiting: A Meta-Analysis},
  author={J. Divatia and J. Vaidya and R. Badwe and R. Hawaldar},
  journal={Anesthesiology},
  year={1996},
  volume={85},
  pages={1055-1062}
}
Background Postoperative nausea and vomiting are important causes of morbidity after general anesthesia. Nitrous oxide has been implicated as an emetogenic agent in many studies. However, several other trials have failed to sustain this claim. The authors tried to resolve this issue through a meta-analysis of randomized controlled trials comparing the incidence of postoperative nausea and vomiting after anesthesia with or without nitrous oxide. Methods Of 37 published studies retrieved by a… Expand
Association between nitrous oxide and the incidence of postoperative nausea and vomiting in adults: a systematic review and meta‐analysis
TLDR
It is concluded that avoiding nitrous oxide does reduce the risk of postoperative nausea and vomiting, especially in women, but the overall impact is modest. Expand
Nitrous Oxide–related Postoperative Nausea and Vomiting Depends on Duration of Exposure
TLDR
No clinically significant effect of nitrous oxide on the risk of PONV exists under an hour of exposure, and this duration-related effect may be via disturbance of methionine and folate metabolism. Expand
THE EFFECT OF NITROUS OXIDE ON POSTOPERATIVE NAUSEA AND VOMITING
Objective: Postoperative nausea and vomiting (PONV) is a common problem and its cause is multifactorial. The relationship between PONV and nitrous oxide is under debate. The aim of this study was toExpand
The Effect of 50 % Nitrous Oxide on Postoperative Nausea-Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Background: Postoperative nausea and vomiting (PONV) is a common problem and its cause is multifactorial. The relationship between PONV and nitrous oxide is under debate. Aim: To evaluate theExpand
The Dose–Response of Nitrous Oxide in Postoperative Nausea in Patients Undergoing Gynecologic Laparoscopic Surgery: A Preliminary Study
TLDR
N2O increases the incidence of postoperative nausea after gynecologic laparoscopic surgery, and a preliminary finding indicates that N2O may increase PONV in a dose-dependent fashion. Expand
Comparison of Anesthetic Techniques for Preventing Postoperative Nausea and Vomiting Undergoing Thyroidectomy
TLDR
The use of propofol for induction and maintenance with combination 50% is the most effective technique at preventing PONV among the three groups within the first 6 hours after thyroidectomy. Expand
Effects of nitrous oxide on intraoperative bowel distension
TLDR
It is determined in a metaanalysis that the chance of having intraoperative bowel distension was increased about two fold in patients receiving nitrous oxide as the anaesthetic carrier gas compared with those receiving nitrogen or oxygen. Expand
Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design.
TLDR
In patients at high risk for PONV, it would therefore make better sense to avoid inhalational anaesthesia rather than simply to add an antiemetic, which may still be needed to prevent or treat delayed vomiting. Expand
Randomized Controlled Trial of Total Intravenous Anesthesia with Propofol versus Inhalation Anesthesia with Isoflurane–Nitrous Oxide: Postoperative Nausea and Vomiting and Economic Analysis
TLDR
Propofol TIVA results in a clinically relevant reduction of postoperative nausea and vomiting compared with isoflurane–nitrous oxide anesthesia (number needed to treat = 6). Expand
Ondansetron in the prophylaxis of postoperative vomiting: a meta-analysis.
TLDR
While ondansetron is an effective antiemetic with minimal adverse effects, the data obtained on the numbers needed to be treated calculation for prophylaxis of postoperative vomiting should be considered in future cost-effective strategies of postoperatively management. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Omitting nitrous oxide in general anaesthesia: meta-analysis of intraoperative awareness and postoperative emesis in randomized controlled trials.
TLDR
Clinically important risk of major harm reduces the usefulness of omitting N2O to prevent postoperative emesis, and the combined NNT to prevent both early and late vomiting with a N1O-free anaesthetic is about 13. Expand
Omitting nitrous oxide in general anaesthesia: meta-analysis of intraoperative awareness and postoperative emesis in randomized controlled trials.
TLDR
Clinically important risk of major harm reduces the usefulness of omitting N2O to prevent postoperative emesis, and the combined NNT to prevent both early and late vomiting with a N1O-free anaesthetic is about 13. Expand
Role of nitrous oxide and other factors in postoperative nausea and vomiting: a randomized and blinded prospective study.
TLDR
It is concluded that there is no association between the use of nitrous oxide and the development of postoperative nausea and vomiting. Expand
The role of nitrous oxide in postoperative nausea and recovery in patients undergoing upper abdominal surgery
TLDR
Omitting nitrous oxide did not decrease the frequency of postoperative nausea, although the symptoms were milder in the air group, and the patients withoutNitrous oxide were alert earlier, in spite of a higher isoflurane concentration. Expand
Nitrous oxide does not increase vomiting in children after myringotomy
TLDR
It is unable to demonstrate that N2O induces vomiting by children after a brief general anaesthetic for myringotomy, as well as whether nitrous oxide has a clinically important effect on postoperative vomiting in children after myringectomy. Expand
Nitrous oxide, nausea, and vomiting after outpatient gynecologic surgery.
TLDR
It was concluded that N2O is associated with an increased prevalence of nausea and vomiting and Fentanyl, given postoperatively for pain, did not increase the prevalence of vomiting. Expand
Postoperative nausea and vomiting. A comparison of sufentanil, nitrous oxide, and isoflurane.
TLDR
Sufentanil, a new synthetic narcotic with a duration as long as fentanyl, was studied with regard to postoperative nausea and vomiting in patients undergoing extra-abdominal procedures. Expand
Nitrous oxide and day-case laparoscopy: effects on nausea, vomiting and return to normal activity.
TLDR
It is concluded that nitrous oxide may be avoided readily in day-case laparoscopy without affecting postoperative morbidity or time taken to return to "street fitness" and normal activity. Expand
Nitrous Oxide Does Not Increase the Incidence of Nausea and Vomiting after Isoflurane Anesthesia
A total of 110 patients undergoing elective abdominal hysterectomy were anesthetized in random order with either isoflurane in nitrous oxide and oxygen or isoflurane in air and oxygen. Fentanyl wasExpand
Propofol for ambulatory gynecologic laparoscopy: does omission of nitrous oxide alter postoperative emetic sequelae and recovery?
TLDR
It is concluded that supplementing prop ofol with nitrous oxide in patients undergoing ambulatory laparoscopy reduces the requirements of propofol, expedites immediate recovery (emergence), and does not increase the incidence of postoperative emesis. Expand
...
1
2
3
4
5
...