Omics for Personalized Medicine

  title={Omics for Personalized Medicine},
  author={Debmalya Barh and Dipali Dhawan and Nirmal Kumar Ganguly},
  booktitle={Springer India},
Pharmaco-Geno-Proteo-Metabolomics and Personalized Medicine-An overview.- Personalized genome, current status and the future of harmacogenomic.- Next generation sequencing (NGS): a revolutionary technology in pharmacogenomics and personalized medicine.- Pharmaco-epigenomics.- Personalized nutrition and drug-nutrient interactions.- Designing and Implementing Pharmacogenomics Study.- Omics approaches and applications in Clinical Trials.- Ethical Considerations in Pharmacogenomics.- Computational… 

Precision medicine for psychopharmacology: a general introduction

The authors review the current state of omics in psychiatry and the future direction of psychopharmacology as it moves towards precision medicine.

Precision medicine, an approach for development of the future medicine technologies

By the birth of precision medicine, novel therapeutic strategies for chronic complex diseases such as cardiovascular disease and cancers would be designed in Systems Medicine.

Pharmacogenomics for Precision Medicine in the Era of Collaborative Co-creation and Crowdsourcing

This short review discusses the state-of-the art of crowdsourcing in genomics research with special focus on pharmacogenomics and a number of ongoing crowdsourcing approaches in the area of pharmacogenetics and personal genomics.

Knowledge Attitude and Practice Study of Pharma- cogenomics amongst Physicians of a Major Indian Metropolitan City

Despite the setback in the existing knowledge prevailing among the physicians, the response from this study towards implementation of PGx in the future remains encouraging.

Knowledge and Attitudes of Medical and Health Science Students in the United Arab Emirates toward Genomic Medicine and Pharmacogenomics: A Cross-Sectional Study

The majority of medical and health science students had positive attitudes but only had a fair level of knowledge, and the top two barriers that students identified in the implementation of genomic medicine and pharmacogenomics were lack of training or education and lack of clinical guidelines.

Oral Anticoagulant Therapy—When Art Meets Science

The data regarding genetic alterations in general and specific populations is reviewed, the diagnosis options in particular cases presenting with genetic alteration causing higher sensitivity and/or resistance to VKA therapy are highlighted and the utility of NOAC is underline in solving such rare and difficult problems.

Biomarkers for military mental health: Insights, challenges, and future prospects

A major limitation in the current treatment of depression is that it is difficult to assess the severity of the depression before and after treatment, and the need for further studies to establish a treatment protocol is not addressed.



Pharmacogenetics: implementing personalized medicine.

  • E. MiniS. Nobili
  • Biology, Medicine
    Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
  • 2009
Although research findings are accumulating, most of the potential of pharmacogenetics and pharmacogenomics remains to be explored and must be validated in prospective randomized clinical trials.

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.

A classification of miRNA polymorphisms/mutations is suggested for the first time to describe the importance and implications of miR-polymorphisms in gene regulation, disease progression, pharmacogenomics and molecular epidemiology.

Pharmacometabonomics as an effector for personalized medicine.

The concept of pharmacometabonomics is introduced and reviews and has major implications for improved efficiency in drug discovery efforts, by enabling more careful selection of animals in preclinical studies, for better stratification of patients in drug clinical trials and for individualized therapies.

Applying the genome to national drug formulary policy in the developing world.

The PharmacoGenetics for Every Nation Initiative (PGENI) is a first step to making pharmacogenetics applicable on a global level and targeted educational efforts will also prepare the Ministry of Health staff from participating countries to better integrate genetic information into many areas of healthcare, including disease management and therapeutic development.

Genomics and personalized medicine.

  • W. Sadee
  • Biology
    International journal of pharmaceutics
  • 2011

Pharmacogenomics Knowledge for Personalized Medicine

The Pharmacogenomics Knowledgebase is a useful source of high‐quality information supporting personalized medicine–implementation projects.

Roadmap to personalized medicine

Abstract Standard clinical protocols and the concept “one drug fits all” that are currently used to treat illness in many cases are not effective, and strikingly so in the treatment of cancer, where

Pharmacogenomics: Challenges and Opportunities

This review will outline progress in the field by describing mechanisms underlying variable drug responses, the potential role of genetic factors in their causes, and contemporary and evolving approaches to identifying these genetic factors.

Pharmacogenomics genes show varying perceptibility to microRNA regulation

A striking difference is identified in the level of miRNA regulation between PK and PD genes, with the former having less than half predicted conserved miRNA binding sites compared with the latter, reflected in a highly significant difference in the shift in expression levels of PD versus PK genes after depletion of miRNAs.