Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.

@article{Inagaki2008OmiH,
  title={Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.},
  author={Reina Inagaki and Kazuhiko Tagawa and Mei-ling Qi and Yasushi Enokido and Hikaru Ito and Takuya Tamura and Shigeomi Shimizu and Kityomitsu Oyanagi and Nobutaka Arai and Ichiro Kanazawa and Erich E. Wanker and Hitoshi Okazawa},
  journal={The European journal of neuroscience},
  year={2008},
  volume={28 1},
  pages={30-40}
}
Selective vulnerability of neurons is a critical feature of neurodegenerative diseases, but the underlying molecular mechanisms remain largely unknown. We here report that Omi/HtrA2, a mitochondrial protein regulating survival and apoptosis of cells, decreases selectively in striatal neurons that are most vulnerable to the Huntington's disease (HD) pathology. In microarray analysis, Omi/HtrA2 was decreased under the expression of mutant huntingtin (htt) in striatal neurons but not in cortical… CONTINUE READING
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