Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

@article{Li2010OmiHtrA2IA,
  title={Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases},
  author={Bojing Li and Qingsong Hu and Hongyan Wang and Na Man and Huan Ren and Lianji Wen and Nobuyuki Nukina and Erkang Fei and Guannan Wang},
  journal={Cell Death and Differentiation},
  year={2010},
  volume={17},
  pages={1773-1784}
}
Omi, also known as high temperature requirement factor A2 (HtrA2), is a serine protease that was originally identified as a proapoptotic protein. Like Smac/Diablo, it antagonizes inhibitor of apoptosis proteins when released into the cytosol on apoptotic stimulation. Loss of its protease activity in mnd2 (motor neuron degeneration 2) mice is associated with neurodegeneration. However, the detailed mechanisms by which Omi regulates the pathogenesis of neurodegenerative disease remain largely… CONTINUE READING
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