Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice.

@article{Mowat1999OmeprazoleAD,
  title={Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice.},
  author={Craig Mowat and Aimee P Carswell and Angela Wirz and Kenneth E. L. McColl},
  journal={Gastroenterology},
  year={1999},
  volume={116 4},
  pages={813-22}
}
BACKGROUND & AIMS Hypochlorhydria is associated with an increased risk of gastric cancer. We have studied the effect of pharmacologically induced hypochlorhydria on the gastric juice ascorbate/nitrite ratio, which regulates the synthesis of potentially carcinogenic N-nitroso compounds. METHODS Saliva, gastric juice, and serum from 20 healthy volunteers (9 positive for Helicobacter pylori), with a mean age of 30 years (range, 20-47 years), were analyzed for nitrite, ascorbic acid, and total… CONTINUE READING