Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells

Abstract

BACKGROUND Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial. Since pancreatic tumours are highly chemoresistant, a logical step would be to investigate the pharmacodynamic, morphological and biochemical effects of omeprazole on pancreatic cancer cell lines… (More)
DOI: 10.1371/journal.pone.0020143

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