Omega-6/omega-3 essential fatty acid ratio: the scientific evidence

@article{Simopoulos2003Omega6omega3EF,
  title={Omega-6/omega-3 essential fatty acid ratio: the scientific evidence},
  author={Artemis P. Simopoulos and Leslie G. Cleland},
  journal={Scandinavian Journal of Nutrition},
  year={2003},
  volume={48},
  pages={49-50}
}
Importance of the Ratio of Omega 6/Omega 3 Essential Fatty Acids - Evolutionary Aspects, Simopoulos, A.P. The Importance of Omega 6/Omega 3 Fatty Acid Ratio in Cell Function - The Gene Transfer of Omega-3 Fatty Acid Desaturase, Kang, J.X. Omega 6/Omega 3 Ratio and Brain-Related Functions, Yehuda, S. Dietary Prevention of Coronary Heart Disease - Focus on Omega 6/Omega 3 Essential Fatty Acid Balance, de Lorgeril, M., Salen, P. Effects of an Indo-Mediterranean Diet on the Omega 6/Omega 3 Ratio in… 

Omega-6/Omega-3 Essential Fatty Acid Ratio and Chronic Diseases

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries that are being exported to the rest of the world.

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries.

Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications.

  • A. Simopoulos
  • Biology, Medicine
    World review of nutrition and dietetics
  • 2009
TLDR
It is argued that a lower ratio of ω-6/ω-3 fatty acids is desirable as it is likely to reduce the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries.

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

TLDR
The omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eICosapentaenoic acid (EPA) and docosahexaenoic Acid (DHA).

The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses

TLDR
A variety of studies are reviewed that suggest that the n-6/n-3 FA ratio is, both on theoretical and evidential grounds, of little value, but Metrics that include the n -3 FAs alone appear to hold the greatest promise.

The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses

  • W. Harris
  • Medicine
    Current atherosclerosis reports
  • 2006
TLDR
A variety of studies are reviewed that suggest that the n-6/n-3 FA ratio is, both on theoretical and evidential grounds, of little value, and metrics that include the n -3 FAs alone appear to hold the greatest promise.

Dietary omega-3 fatty acid, ratio of omega-6 to omega-3 intake, inflammation, and survival in long-term hemodialysis patients.

TLDR
Higher dietary omega-6 to omega-3 ratio appears to be associated with both worsening inflammation over time and a trend toward higher death risk in hemodialysis patients, and may underestimate actual dietary fat intake at an individual level.

Omega-3 fatty acids, cognitive impairment and Alzheimer's disease

TLDR
The small body of evidence indicating that omega-3 fatty acids are depleted in those with already manifest cognitive disorders is discussed and the possibility that elevating omega- 3 fatty acid status in such individuals may benefit their cognition is discussed.

Fatty acid profile of the erythrocyte membranes of healthy Bahraini citizens in comparison with coronary heart disease patients.

TLDR
The findings in this study suggest that the low dietary value of fish from Bahrain water may have resulted in a modest dietary intake of DHA and eicosapentanoic acid (EPA, 20:5 n-3), which might have been the reason behind the high incidence of coronary heart disease in Bahrain.

Serum Omega-6/Omega-3 Ratio and Risk Markers for Cardiovascular Disease in an Industrial Population of Delhi

TLDR
The levels of total cholesterol, triglycerides, ldl-cholesterol and cholesterol/hdl ratio and apo B correlated significantly with omega-6/3 ratio and there was no correlation observed with hsCRP and LDL-particle size.
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References

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