Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis

@article{Rizos2020Omega3SA,
  title={Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis},
  author={Evangelos C. Rizos and Georgios Markozannes and Apostolos Tsapas and Christos S. Mantzoros and Evangelia E. Ntzani},
  journal={Heart},
  year={2020},
  volume={107},
  pages={150 - 158}
}
Background Omega-3 supplements are popular for cardiovascular disease (CVD) prevention. We aimed to assess the association between dose-specific omega-3 supplementation and CVD outcomes. Design We included double-blind randomised clinical trials with duration ≥1 year assessing omega-3 supplementation and estimated the relative risk (RR) for all-cause mortality, cardiac death, sudden death, myocardial infarction and stroke. Primary analysis was a stratified random-effects meta-analysis by omega… 
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