Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions.

@article{Zhang2010Omega3PF,
  title={Omega-3 polyunsaturated fatty acid supplementation confers long-term neuroprotection against neonatal hypoxic-ischemic brain injury through anti-inflammatory actions.},
  author={Wenting Zhang and Xiaoming Hu and Wei Yang and Yanqin Gao and Jun Chen},
  journal={Stroke},
  year={2010},
  volume={41 10},
  pages={2341-7}
}
BACKGROUND AND PURPOSE Current available therapies for neonatal hypoxia/ischemia (H/I) brain injury are rather limited. Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates. METHODS Female rats were treated with or without an omega-3 polyunsaturated fatty acids-enriched diet from the second day of pregnancy until 14 days after parturition. Seven-day-old neonates were subjected to H/I and euthanized 5… CONTINUE READING

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