Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

@inproceedings{Chen2017Omega3PF,
  title={Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury},
  author={Xiangrong Chen and Shukai Wu and Chunnuan Chen and Baoyuan Xie and Zhongning Fang and Weipeng Hu and Junyan Chen and Huangde Fu and Hefan He},
  booktitle={Journal of Neuroinflammation},
  year={2017}
}
Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs) to activate downstream signaling pathways, such as the nuclear factor (NF)-κB signaling pathway, leading to a cascade… CONTINUE READING
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