Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis.

  title={Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis.},
  author={Shufan Wu and Yang Guo and Yikuan Wu and Shenglong Zhu and Zhao He and Yong Q. Chen},
  journal={Biochemical and biophysical research communications},
  volume={459 2},
Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (ω-3FFA) with tamoxifen leads to improved treatment in breast cancer. In this study, we observed that ω-3FFA induces MCF-7 cell apoptosis to suppress cell growth. The treatment of breast cancer cells with ω-3FFA attenuated tamoxifen-induced cell… CONTINUE READING