Omega-3 fatty acids in health and disease and in growth and development.

@article{Simopoulos1991Omega3FA,
  title={Omega-3 fatty acids in health and disease and in growth and development.},
  author={Artemis P. Simopoulos},
  journal={The American journal of clinical nutrition},
  year={1991},
  volume={54 3},
  pages={
          438-63
        }
}
  • A. Simopoulos
  • Published 1 September 1991
  • Medicine, Biology
  • The American journal of clinical nutrition
Several sources of information suggest that man evolved on a diet with a ratio of omega 6 to omega 3 fatty acids of approximately 1 whereas today this ratio is approximately 10:1 to 20-25:1, indicating that Western diets are deficient in omega 3 fatty acids compared with the diet on which humans evolved and their genetic patterns were established. Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibrinogen; and increase erythrocyte deformability… 

The omega-6/omega-3 fatty acid ratio: health implications

TLDR
A target of omega-6/omega-3 fatty acid ratio of 1:1 to 2:1 appears to be consistent with studies on evolutionary aspects of diet, neurodevelopment and genetics, and the need of balanced dietary intake essential for health and disease prevention.

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries.

The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease.

  • A. Simopoulos
  • Medicine, Biology
    Asia Pacific journal of clinical nutrition
  • 2008
TLDR
The diet-gene interaction suggests that dietary omega-6 fatty acids promote, whereas marine omega-3 fatty acids EPA and DHA inhibit leukotriene-mediated inflammation that leads to atherosclerosis in this subpopulation.

Omega-6/Omega-3 Essential Fatty Acid Ratio and Chronic Diseases

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries that are being exported to the rest of the world.

The importance of the ratio of omega-6/omega-3 essential fatty acids.

  • A. Simopoulos
  • Medicine
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2002

Polyunsaturated fatty acids in biology and diseases The importance of the ratio of omega-6 / omega-3 essential fatty acids

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries, that are being exported to the rest of the world.

Omega-3 fatty acids and cardiovascular disease: The epidemiological evidence

  • A. Simopoulos
  • Medicine
    Environmental health and preventive medicine
  • 2002
TLDR
In population-based case-control studies, the patients consuming modest amounts of fish had a significant lower risk of primary cardiac arrest compared with those who did not eat fish at all, and the intake of eicosapentaenoic acid and docosahexaenoic acids as reflected in adipose tissue content is inversely associated with risk of myocardial infarction.

Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.

  • A. Simopoulos
  • Medicine, Biology
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2006

An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

TLDR
The omega-6/omega-3 ratio plays an important role in increasing the development of obesity via both AA eicosanoid metabolites and hyperactivity of the cannabinoid system, which can be reversed with increased intake of eICosapentaenoic acid (EPA) and docosahexaenoic Acid (DHA).

Dossier : Polyunsaturated fatty acids in biology and diseases The importance of the ratio of omega-6 / omega-3 essential fatty acids

TLDR
A lower ratio of omega-6/omega-3 fatty acids is more desirable in reducing the risk of many of the chronic diseases of high prevalence in Western societies, as well as in the developing countries, that are being exported to the rest of the world.
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