Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.
@article{Lakhwani2007Omega3FA, title={Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.}, author={Lalit Lakhwani and Sudheer K Tongia and V. S. Pal and R. P. Agrawal and Prem Nyati and P. Phadnis}, journal={Acta poloniae pharmaceutica}, year={2007}, volume={64 3}, pages={ 271-6 } }
Forced swimming test is used to induce a characteristic behavior of immobility in rats, which resembles depression in humans to some extent. We evaluated the effect of omega-3 fatty acids alone as well as compared it with the standard antidepressant therapy with fluoxetine in both acute and chronic studies. In both the studies, rats were divided into 4 groups and subjected to the following drug interventions - Group 1- control: Group 2- fluoxetine in dose of 10 mg/kg subcutaneously 23.5, 5 and… CONTINUE READING
Paper Mentions
47 Citations
Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression.
- Biology, Medicine
- Journal of psychiatric research
- 2014
- 18
Potentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapine.
- Psychology, Medicine
- European journal of pharmacology
- 2010
- 27
Omega-3 fatty acids improve behavioral coping to stress in multiparous rats
- Psychology, Medicine
- Behavioural Brain Research
- 2015
- 8
Effects of omega-3 on behavioral and biochemical parameters in rats submitted to chronic mild stress
- Medicine
- Metabolic Brain Disease
- 2014
- 14
- Highly Influenced
N-3 polyunsaturated fatty acids and 17β-estradiol injection induce antidepressant-like effects through regulation of serotonergic neurotransmission in ovariectomized rats.
- Biology, Medicine
- The Journal of nutritional biochemistry
- 2015
- 18
Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats
- Biology, Medicine
- Pharmacology Biochemistry and Behavior
- 2013
- 12
Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents.
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 2014
- 14
N-3 PUFA Have Antidepressant-like Effects Via Improvement of the HPA-Axis and Neurotransmission in Rats Exposed to Combined Stress
- Medicine
- Molecular Neurobiology
- 2020
Effect of omega-3 polyunsaturated fatty acid treatment over mechanical allodynia and depressive-like behavior associated with experimental diabetes
- Medicine
- Behavioural Brain Research
- 2016
- 21
References
SHOWING 1-10 OF 28 REFERENCES
Br
- J. Psychiatry 152, 4
- 1988
Biol
- Psychiatry 54, 70
- 2003
Pain Med
- 4, 63
- 2003
Psychosom
- Med. 65, 362
- 2003
Semin
- Clin. Neuropsychiatry 8, 109
- 2003
Arch
- Gen. Psychiatry 58, 512
- 2001
Am
- J. Clin. Nutr. 71, 343S
- 2000