Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?

@article{Guo2014Omega3FA,
  title={Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?},
  author={Xue‐yuan Guo and Xianliang Yan and Ying-Wei Chen and Ribo Tang and Xin Du and Jian-zeng Dong and Changsheng Ma},
  journal={Heart, lung \& circulation},
  year={2014},
  volume={23 8},
  pages={
          743-50
        }
}
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TLDR
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References

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Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: a meta-analysis.
n-3 Polyunsaturated fatty acids for the prevention of postoperative atrial fibrillation: a meta-analysis of randomized controlled trials
TLDR
It is suggested that preoperative n-3 PUFA therapy may not reduce POAF in patients undergoing cardiac surgery, however, several aspects may have influenced this negative result, which need to be investigated.
Omega-3 fatty acids in the prevention of atrial fibrillation recurrences after cardioversion: a meta-analysis of randomized controlled trials.
TLDR
More double-blind, randomized, placebo-controlled, multicenter studies with high quality and longer follow-up periods are needed to affirm the conclusion that omega-3 fatty acids had no significant effect on the prevention of atrial fibrillation recurrences after cardioversion.
N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial.
A Randomized, Placebo-Controlled Trial of Omega-3 Fatty Acids for Inhibition of Supraventricular Arrhythmias After Cardiac Surgery: The FISH Trial
TLDR
Oral n3-PUFA supplementation begun 2 days before CABG did not reduce AF or other complications after surgery, and this hypothesis was tested in a well-powered, randomized, double-blind, placebo-controlled, multicenter clinical trial.
Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study.
TLDR
The data suggest that perioperative intravenous infusion of PUFA should be recommended for patients undergoing CABG and leads to a shorter stay in the ICU and in hospital.
Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
TLDR
Omega-3 PUFA do not reduce the risk of AF after coronary artery bypass graft surgery and there was no significant difference between groups in the primary outcome of AF or in any of the secondary outcomes or in AF-free survival.
Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial.
TLDR
Since the antioxidant supplementation with n-3 PUFAs and vitamins C and E resulted in a more marked reduction of postoperative AF in older patients, it could be suggested that the efficacy of this therapy improves with ageing.
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