Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?

@article{Guo2014Omega3FA,
  title={Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?},
  author={Xue‐yuan Guo and Xianliang Yan and Ying-Wei Chen and Ribo Tang and Xin Du and Jian-zeng Dong and Changsheng Ma},
  journal={Heart, lung \& circulation},
  year={2014},
  volume={23 8},
  pages={
          743-50
        }
}
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20 Citations
Background Citations
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20 Citations

N-3 polyunsaturated fatty acids for prevention of postoperative atrial fibrillation: updated meta-analysis and systematic review
TLDR
PUFA appears to reduce the incidence of POAF, however, the said protective effect may be influenced by EPA/DHA ratio, with < 1 appearing preferable.
Omega-3 polyunsaturated fatty acids in cardiac surgery patients: An updated systematic review and meta-analysis.
Omega-3 Index and Anti-Arrhythmic Potential of Omega-3 PUFAs
TLDR
The purpose of this updated review is to focus on the novel cellular and molecular effects of omega-3 PUFAs, in the context of the mechanisms and factors involved in the development of cardiac arrhythmias; to provide results of the most recent studies on the omega- 3 PUFA anti-arrhythmic efficacy and to discuss the lack of the benefit in relation to omega-2 PUFA status.
Polyunsaturated Fatty Acids in Cardiac Surgery Patients : A Hearty Win for the Fish
TLDR
After aggregating 10 randomized controlled trials (RCTs) reporting clinical outcomes of FO-IVFEs in critically ill patients, the authors found a significant reduction in infections and a tendency toward a reduction in mechanical ventilation days and hospital length of stay, as well as a trend to reduced overall mortality in those patients who were enterally fed.
ω-3 Polyunsaturated Fatty Acids in Cardiac Surgery Patients.
Anti-inflammatory drugs in the prevention of post-operative atrial fibrillation: a literature review
TLDR
Current data fail to support their efficacy in POAF prevention in the case of n-3 polyunsaturated fatty acids and NSAIDs, and perioperative administration of NSAIDs may be associated with some severe safety considerations.
Fish oil supplementation for primary prevention of atrial fibrillation after coronary artery bypass graft surgery: A randomized clinical trial.
The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial
TLDR
Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo CABG surgery.
Oxidative stress and atrial fibrillation: an update
TLDR
An updated review provides a concise and critical overview of all available data regarding oxidative stress and its modulation in atrial fibrillation and suggests lifestyle, diet, and risk factors modification is a complementary promising approach.
Antioxidants in Arrhythmia Treatment—Still a Controversy? A Review of Selected Clinical and Laboratory Research
TLDR
Although few clinical trials have been conducted, the use of antioxidants in treating arrhythmias is an interesting prospect and promising results also apply to polyphenols, nitric oxide synthase inhibitors and MitoTEMPO.
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References

SHOWING 1-10 OF 35 REFERENCES
Efficacy and safety of omega-3 fatty acids for the prevention of atrial fibrillation: a meta-analysis.
n-3 Polyunsaturated fatty acids for the prevention of postoperative atrial fibrillation: a meta-analysis of randomized controlled trials
TLDR
It is suggested that preoperative n-3 PUFA therapy may not reduce POAF in patients undergoing cardiac surgery, however, several aspects may have influenced this negative result, which need to be investigated.
Omega-3 fatty acids in the prevention of atrial fibrillation recurrences after cardioversion: a meta-analysis of randomized controlled trials.
TLDR
More double-blind, randomized, placebo-controlled, multicenter studies with high quality and longer follow-up periods are needed to affirm the conclusion that omega-3 fatty acids had no significant effect on the prevention of atrial fibrillation recurrences after cardioversion.
N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial.
A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement.
A Randomized, Placebo-Controlled Trial of Omega-3 Fatty Acids for Inhibition of Supraventricular Arrhythmias After Cardiac Surgery: The FISH Trial
TLDR
Oral n3-PUFA supplementation begun 2 days before CABG did not reduce AF or other complications after surgery, and this hypothesis was tested in a well-powered, randomized, double-blind, placebo-controlled, multicenter clinical trial.
Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial electrophysiology.
Beneficial effects of intravenously administered N-3 fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a prospective randomized study.
TLDR
The data suggest that perioperative intravenous infusion of PUFA should be recommended for patients undergoing CABG and leads to a shorter stay in the ICU and in hospital.
Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
TLDR
Omega-3 PUFA do not reduce the risk of AF after coronary artery bypass graft surgery and there was no significant difference between groups in the primary outcome of AF or in any of the secondary outcomes or in AF-free survival.
Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial.
TLDR
Since the antioxidant supplementation with n-3 PUFAs and vitamins C and E resulted in a more marked reduction of postoperative AF in older patients, it could be suggested that the efficacy of this therapy improves with ageing.
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