Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA.

@article{Doughman2007Omega3FA,
  title={Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA.},
  author={Scott D Doughman and Srirama Krupanidhi and Carani B. Sanjeevi},
  journal={Current diabetes reviews},
  year={2007},
  volume={3 3},
  pages={
          198-203
        }
}
Long-chain EPA/DHA omega-3 fatty acid supplementation can be co-preventative and co-therapeutic. Current research suggests increasing accumulated long chain omega-3s for health benefits and as natural medicine in several major diseases. But many believe plant omega-3 sources are nutritionally and therapeutically equivalent to the EPA/DHA omega-3 in fish oil. Although healthy, precursor ALA bio-conversion to EPA is inefficient and production of DHA is nearly absent, limiting the protective value… 

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    References

    SHOWING 1-10 OF 66 REFERENCES
    Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids.
    BACKGROUND For many persons who wish to obtain the health benefits provided by dietary n-3 fatty acids, daily ingestion of fish or fish oil is not a sustainable long-term approach. To increase the
    Achieving optimal essential fatty acid status in vegetarians: current knowledge and practical implications.
    TLDR
    Total n-3 requirements may be higher for vegetarians than for nonvegetarians, as vegetarians must rely on conversion of ALA to EPA and DHA, although the response is generally less for ALA than for EPA andDHA.
    Dietary n-6 and n-3 fatty acid balance and cardiovascular health.
    Epidemiological and clinical studies have established that the n-6 fatty acid, linoleic acid (LA), and the n-3 fatty acids, linolenic acid (LNA), eicosapentaenoic acid (EPA), and docosahexaenoic acid
    Omega 3 fatty acids and cardiovascular disease—fishing for a natural treatment
    TLDR
    The current evidence regarding fish oils and cardiovascular disease, their possible mechanism of action, and potential future developments and research strategies are reviewed.
    Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial.
    Triacylglycerol (TG) lowering effects of n-3 long-chain PUFA (n-3 LCPUFA) have been repeatedly demonstrated, but studies investigating the individual effects of EPA or DHA on plasma TG and
    Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women
    TLDR
    DHA supplementation at a dose of 2.14 g/day for 42 days decreases plasma cholesterol but neither does it show beneficial effects on estrogen metabolism, nor does it induce deleterious effects on the observed in vivo antioxidant or oxidative stress marker in postmenopausal vegetarian women.
    Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6n-3) and docosapentaenoic acid (22:5n-6) on cardiovascular risk factors in healthy men and women
    TLDR
    The oil was well tolerated and did not adversely affect cardiovascular risk, and Factor VII (FVII) coagulant activity increased by 12% following active treatment.
    Dietary n-3 fatty acid intake and risk of sudden death and coronary artery disease
    • C. Albert
    • Medicine
      Current treatment options in cardiovascular medicine
    • 2007
    Opinion statementBased upon the data from observational epidemiologic studies and randomized clinical trials that are summarized in this article, as well as plausible mechanisms for benefit, the
    Distribution, interconversion, and dose response of n-3 fatty acids in humans.
    TLDR
    It is concluded that the most predictable way to increase a specific long-chain n-3 fatty acid in plasma, tissues, or human milk is to supplement with the fatty acid of interest.
    ...
    ...